Abstract
In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.
Highlights
The tissue engineering approach to repair and regeneration is founded upon the use of polymer scaffolds which serve to support, reinforce and in some cases organize the regenerating tissue [1,2,3]
The materials used for the synthesis of Carboxymethyl chitosan (CMC) is chitosan that was extracted from waste prawn shell and was collected from export oriented prawn farm located at the northern part Bangladesh
These results indicated that the carboxymethylation process had occurred at the C6 position of chitosan
Summary
The tissue engineering approach to repair and regeneration is founded upon the use of polymer scaffolds which serve to support, reinforce and in some cases organize the regenerating tissue [1,2,3]. Natural polymers have great resemblance to natural ECM elements, especially in biocompatibility and biodegradability, and have gained much attention as scaffold materials [4]. A number of natural and synthetic polymers are currently being employed as tissue scaffolds. The microstructures of these systems span the range from hydrogels, to open-pore structures, to fibrous matrices [5,6,7]. Since the range of potential tissue engineered systems is broad, there is a continuous ongoing search for materials which either possess desirable tissuespecific properties, or which may have broad applicability and can be tailored to several tissue systems [1]
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