Abstract
Purpose: This study aims to prepare a novel, natural nanoparticle (NP) as a drug carrier, which also has inherent therapeutic effects. Methods: Pistacia khinjuk gum NPs were prepared and Response surface methodology (RSM) was used for statistical analysis of data and optimizing the size of NPs. Results: NPs were in the range of 75.85–241.3 nm. The optimization study was carried out, and an optimized size (70.86nm) was obtained using DMSO as a solvent. The volume of the organic phase was 111.25µl, and the concentration of gum was 1% w/v. The cell viability assay was performed on the pure gum and NPs toward β-TC3, MCF7, and HT29 cell lines. It was observed that NPs have higher cytotoxic activity in comparison with pure gum, and that the IC50value was achieved at 1% of NPs in β-TC3 cells. The obtained NPs demonstrated antibacterial activity against two bacterial strains (Pseudomonas aeruginosa and Staphylococcus aureus). Conclusion: Altogether, according to the obtained results, these NPs with inherent cytotoxicity and antibacterial activity are an attractive carrier for drug delivery.
Highlights
Pistacia khinjuk is one of the major Pistacia species that grows in some of Mediterranean countries and classified into the Anacardiaceae family
Purpose: This study aims to prepare a novel, natural nanoparticle (NP) as a drug carrier, which has inherent therapeutic effects
The response function was fitted by a quadratic polynomial model
Summary
Pistacia khinjuk is one of the major Pistacia species that grows in some of Mediterranean countries (they have especially been widely distributed in the Zagrossian region of Iran) and classified into the Anacardiaceae family. Khinjuk has exhibited inherent anti-inflammatory, antileishmanial, antipyretic, antioxidant, antitumor, antiviral, antiasthmatic, and antimicrobial properties.[2,6,7] In addition to these common medical applications, p.khinjuk gum could be a candidate as a new natural biopolymer for drug delivery systems. According to the literature review, the fabrication of p.khinjukgum NPs and using them as a novel delivery vehicle has not been previously investigated. Due to the numerous desirable characteristics and advantages of p.khinjuk gum in therapeutic objectives, the fabrication of p.khinjuk gum NPs as drug carriers was investigated in this study. The obtained data was statistically analyzed using RSM, which combines statistical and mathematical techniques to fit experimental data to the model for optimization processes.[8]
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