Abstract
AbstractAs ideal tissue engineering scaffold, surface feature plays an important role in cell adhesion and proliferation. In order to improve cytocompatibility of poly(3‐hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) and polyethylene oxide (PEO) synthetic materials, in this study, photochemical surface modification is applied in electrospinning field for the first time. Azidobenzoic acid‐modified gelatin (AZ‐gelatin) as bioactive protein is successfully fixed on PHBV/PEO electrospun mats by photochemical technique without any crosslinking agent. In vitro degradation and cell culture results show that PHBV/PEO/AZ‐gelatin electrospun mats have excellent cell adhesion and proliferation compared with PHBV and PHBV/PEO electrospun mats. But, by contrast with PHBV/PEO electrospun mats, the fiber diameter of PHBV/PEO/AZ‐gelatin mats increased, and the porosity and mechanical properties decrease. Nonetheless, PHBV/PEO/AZ‐gelatin‐0.01 mg mL−1 electrospun mats have shown better morphology (fiber diameter 600 nm, porosity 88%), mechanical properties (4.2 MPa), and water vapor transmission rate (2301 g m−2 day−1), which has great potential as artificial skin scaffold in tissue regeneration field.
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