Abstract
In this study, a temperature responsive PGS/PLLA@PNIPAM core-shell nanofiber membrane was prepared by combining electrospinning with surface ATRP grafting polymer technology, in which the core layer of PGS/PLLA nanofiber was prepared by electrospinning, and then the shell layer of temperature responsive PNIPAM polymer was grafted on the nanofiber surface by ATRP reaction. In the experiment, a macromolecule-initiator PGS-Br was prepared and characterized by FTIR and 1H NMR. The surface morphology, composition, element of the core-shell nanofiber membrane were characterized by SEM, FTIR, and XPS. In addition, it is worth noting that the core-shell nanofiber membrane can respond to temperature in drug release tests.
Highlights
Electrospinning is a simple, fast, and efficient method for preparing nanofibers with the diameter from a few nanometers to tens of nanometers.[1]
As shown in Scheme 1, the preparation process of the PGS/PolyL-lactic acid (PLLA)@polyn-isopropyl acrylamide (PNIPAM) nanofiber membrane consists of two main steps: synthesis of the macro-initiator PGS-Br and grafting PNIPAM polymer by AGET-ATRP on the surface of electrospun PGS/PGS-Br/PLLA nanofiber membrane
The PGS/PGS-Br/PLLA-grafting-PNIPAM polymer was synthesized by AGET-ATRP reaction, the FTIR spectrum of PGS in Figure 1(d) shows the peaks for –CO–NH– at 1640 cm−1 and the peaks for –NH– at 3440 cm−1, which is completely consistent with the previous report
Summary
Electrospinning is a simple, fast, and efficient method for preparing nanofibers with the diameter from a few nanometers to tens of nanometers.[1]. The obtained PGS/ PGS-Br@PLLA nanofiber membrane was exposed on room temperature to evaporate any residual solvent.
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