Preparation and characterization of microspheres embedded hydrogels for controlled release of avermectin

Abstract

In this study, using sodium alginate and chitosan as carrier materials, release- controlled microspheres loaded avermectin were prepared by complex coacervation method, the drug grinding time and sodium alginate concentration were determined, and the drug loading rate and entrapment efficiency of the prepared microspheres were 30.38% and 81.47%, respectively. At the same time, the composite systems of microspheres Impregnated CS-PVA hydrogels were prepared. The influence of pH and temperature on swelling ratio of microspheres and composite systems were determined. Results showed that microspheres and composite systems have good pH and temperature responsive behavior. The release time of avermectin could be prolonged by embedding microspheres into the hydrogels, and the release mechanism of abamectin in microspheres and composite system Ⅲall fit no-Fick diffusion.