Abstract
Magnetic star-shaped amphiphilic copolymers (S-Fe3O4-PLA-b-MPEG) consisting of Fe3O4 as the core, poly(L,D-lactide) (PLA) as the inner layer, and monomethyl polyethylene glycol (MPEG) as the out shell were synthesized. The syntheses included ring-opening polymerization of L,D-lactide initiated by hydroxyl modified Fe3O4 (Fe3O4-(OH) n), followed by the esterification of the PLA with MPEG. The structure of the star block copolymers were characterized by Fourier Transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, transmission electron microscopy, nanoparticle size analyzer, and vibrating sample magnetometer. The nanoparticles in aqueous solution were made from the amphiphilic star copolymer. The average size of the nanoparticles was adjustable and increased with the increase of the PLA segments in the copolymer. The cytotoxicity grade of the nanoparticles was zero determined by the analysis of cytotoxicity. The nanoparticles could potentially be used as the drug vehicles for magnetic-response controlled release. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers
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