Preparation and Characterization of Inorganic Organic Hybrid Material Based on TEOS/MAPTMS for Biomedical Applications

Abstract

In this study, inorganic-organic hybrid material consisting of tetraethyl orthosilicate (TEOS) and 3-methacryloxypropyl trimethoxysilane (MAPTMS) were prepared with sol-gel process and evaluated as a bioactive bone substitute. The hydrolysis and condensation were attained in an (ethanol/water) solution. Different molar ratios of TEOS/MAPTMS [(1:0), (1:1), (1:2), (1:3) and (1:4)] [M0, M1, M2, M3, M4] respectively were proposed. The molar proportion of silane to water to ethanol was 1:3:3. Bioactivity of all samples was studied via in-vitro test by immersion in simulated body fluid (SBF) to evaluate the creation of a calcium phosphate (CP) layer on the surface of specimens. Structural characterization of the prepared samples was performed using X -ray diffraction (XRD) and fourier transform infrared (FTIR) spectroscopy while the morphology of the samples was examined using scanning electron microscopy (SEM) equipped with an energy dispersive x-ray analysis (EDXA). Results showed the formation of a layer of hydroxyl apatite (HA) on the surface of all samples. As the polymer amount increases the nucleation sites and surface porosity increase, which improve the bioactivity of the sample surface. HA layer increased with increasing the concentration of MAPTMS.