Abstract
Cyclodextrins have found wide application in contemporary chemistry, pharmacy and medicine. Because of their unique properties, cyclodextrins are constantly used in research on solubility or stability improvement, as well as other physicochemical properties of medicinal substances. Indomethacin (IND) is a photolabile molecule that also attracts the interest of researchers due to its therapeutic potential and the need to overcome its problematic photosensitivity. Supramolecular complexes of indomethacin with β-cyclodextrin (CD) are already known, and they show greater stability compared to complexes with other types of cyclodextrins. So far, however, the sensitivity to light of physical mixtures and inclusion complexes in the solid phase has not been studied, and their various stoichiometries have not yet been investigated. Due to this fact, the aim of the present study is to obtain supramolecular systems (inclusion complexes and physical mixtures) of indomethacin with three different amounts of β-cyclodextrin. Assessment of the photochemical stability of indomethacin-β-cyclodextrin systems in the solid state is performed in order to find the best correlation between IND stability and the amount of CD. Comparative analysis of physicochemical degradation for stoichiometry systems [CD:IND] = [1:1], [0.5:1] and [0.1:1] is performed by using ultraviolet spectroscopy, transmission—FTIR, reflection—ATR-FTIR infrared spectroscopy and DSC calorimetry.
Highlights
All medicines can cause unwanted side effects
The International Council for Harmonization (ICH) Q1B [26] standard provides information on testing the photostability of new substances and medicinal products. These guidelines indicate that the purpose of photodegradation is to assess the sensitivity of photosensitive molecules to a given stress factor, to develop an appropriate analytical method and to explain the mechanisms of degradation [27]
It should be stressed that the results described in this paper point to the important role of the stoichiometry and the existence of proper hydrogen bonds in determining the thermodynamic balance and influence on stability of each system [48]
Summary
All medicines can cause unwanted side effects. Most side effects are due to interactions between prescription, over-the-counter and complementary medicines. All possible details on drug photodegradation are always helpful in order to minimize side effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. An attractive and frequently used method is the formation of cyclodextrin inclusion complexes with the active ingredient molecule. This allows, among other things, the protection of physicochemical labile particles, the so-called “guest”, against environmental factors to which the substance is exposed during technological processes, transport or patient use
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
