Abstract

In the present study, polyethylene glycol fumarate (PEGF) was synthesized as a component of blend solutions via polycondensation polymerization and characterized by different tests in order to determine its functional groups and its physical properties included melting and crystallization temperature, enthalpy of fusion and average molecular weights. Wound dressing films based on chitosan (Ch), PEGF and thymol (Th) were fabricated by solvent casting method with different formulations contained 80%(w/w) chitosan and 20%(w/w) PEGF as polymeric components and different amounts of thymol consisted of 0, 0.6, 1.2 and 1.8%(v/v) as pharmaceutical additives of blend solutions. These films were evaluated by different essential tests included Fourier transform infrared spectroscopy (FTIR), tensile testing, water vapor transmission rate (WVTR), water vapor uptake, equilibrium water uptake, water solubility, swelling, scanning electron microscopy (SEM) and antibacterial activity tests. The blend film contained 1.8%(v/v) thymol demonstrated optimal properties included acceptable mechanical properties, better absorption of water vapor or liquid water, higher water vapor transmission rate and air permeability, acceptable water solubility, superior swelling level, more porous structures and rough surfaces and the excellent antibacterial activity against both gram-negative and gram-positive bacteria which make it a suitable candidate for wound dressing applications.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.