Abstract
In this study, a modified chitosan was chemically synthesized from chitosan in two steps, (1) addition of methyl acrylate followed by (2) diethylenetriamine. The modified chitosan (MC) characterized by FT-IR spectroscopy and was used as carrier for loading of ibuprofen (IBU), an anti-inflammatory drug. Hence, a series of IBU/MC composites were prepared and the drug release of the composites was investigated by using UV–Vis absorbance technique. In order to improve the release behaviour of composites, they were coated with different amounts of TiO2 (30–60 wt%) using titanium tetra n-butoxide, as precursor. The prepared IBU/MC/TiO2 hybrid composites were characterized by FT-IR, TG, XRD, FE-SEM, DSC, BET, DLS and Zeta potential analysis. Coating with TiO2 enhanced the drug entrapment considerably, and reduced the drug release, so that uncoated and coated composites had drug release over 24 h and 54, respectively. Moreover, hybrid composites of IBU/MC/TiO2 revealed that drug release is pH sensitive. The release rate of IBU in the simulated gastric fluid (pH 1.2) was noticeably slower than pH 7.4. The results indicate that the prepared hybrid composites could decrease side effects of the drug by minimizing the contact between the drug and the gastric fluid.
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