Abstract
Fe3O4@SiO2@nimodipine(NMDP) core-shell structure nanoparticles were prepared successfully by sonochemical method. The composite magnetic nanoparticles with SiO2 coating are effective and accurate for completing the delivery of NMDP in vitro. The samples are characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR). Drug release was detected by high performance liquid chromatography (HPLC). The result shows the release rate of NMDP reach to 61.3% in a short time of 40min in the PBS, and to 100% in a time of 60min. The Fe3O4@SiO2@NMDP NPs prepared show a super-paramagnetic property with a saturation magnetization value of 21.4emu/g. The accordingly composite magnetic fluid with a saturation magnetization value of 14.8emu/g shows the spicules in external magnet field. It indicates that SiO2 coating plays an important role and has a great potential application in treatment of high blood pressure and cerebrovascular disease by using magnetic drug delivery technology.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
