Abstract
Nanosponges (NS) of etodolac(ETO) was prepared using the emulsion solvent diffusion method ; the effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized, The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug: PVA:EC in ratio 1:3:2 is the best with smallest particle size 40.2±0.098 with polydispersibility0.005 and in vitro release 97.6±0.11%, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel.
Highlights
The most significant challenge with topical drug delivery is the barrier nature of the skin that restricts the entry of most drugs, to increase the therapeutic effectiveness of the existing drug molecules is by formulating them using novel nanocarrier systems and incorporating them into topical preparations [1]
Emulsion solvent diffusion method, solvent method and hyper cross-linked - cyclodextrins [2]; Pervious work on NS ; like using Lemongrass oil a volatile oil extracted from the leaves of Cymbopogon citratus incorporated in an EC NS revealed that the spongy structure with minute pores and the sustained integrity of the NS structure when incorporated in the hydrogel showed no skin irritation and increasing bioavailability [2]
This study presents a new approach for the modification of polymeric nanoparticles as well as a new system for enhancing dissolution and release of poorly soluble drugs
Summary
The most significant challenge with topical drug delivery is the barrier nature of the skin that restricts the entry of most drugs, to increase the therapeutic effectiveness of the existing drug molecules is by formulating them using novel nanocarrier systems and incorporating them into topical preparations [1]. Nanosponges are a novel class of nanoparticles, exhibiting promising potential in controlled drug delivery, especially topical formulations. Define Nanosponges(NS) as biocompatible porous nanoparticles formulate as nano-sized colloidal carriers having the shape of tiny sponges in nature; with a size of about a virus and the average diameter (250 nm -1μm) which will fill with a variety of materials. ETO is a weakly acidic drug that belongs to the Biopharmaceutical Classification System (BCS) class II type (practically water insoluble).
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