Preparation and characterization of encapsulation of multiple lipid carrier (MLC) using vegetable fat

Abstract

The goal of this study is to establish the characterization of lipid carriers of a water-in-oil-in-water (W/O/W) emulsion formation containing unstable hydrophilic active ingredients with an anti-wrinkle or whitening function, such as lipoic acid derivatives. In this experimental study, micrographs of multiple lipid carriers (MLCs) show that they are usually spherical, with a multiple emulsion droplet and multi-lamellar structure. It is shown that particle size and loading capacity are influenced by the concentration of hydrophilic or hydrophobic emulsifier, electrolyte content, and the type of thickening agent. The particle’ diameter varied from about 27 μm to 361 μm, and the encapsulation efficiencies ranged from 18.3% to 80.7%. It was noted that particle’ droplet breakdown was accelerated with the emulsifier content. The characterizations of MLC were dependent on the composition and choice of media. When the free methoxy PEG-45 thiocate was radiated using ultraviolet light (6.156 J/cm 2), the residual content of methoxy PEG-45 thiocate rapidly decreased, but the residual content of methoxy PEG-45 thiocate encapsulated by MLC did not change much. Therefore, the lipid membrane of MLC act as a physical shielding membrane and leads to long-term storage stability in the drug, improving its photochemical stability against ultraviolet light.