Abstract
The present study aimed to prepare nanofibers by electrospinning in the system polylactic acid-hydroxyapatite-doxycycline (PLA-HAP-Doxy) to be used as a drug delivery vehicle. Two different routes were employed for the preparation of Doxy-containing nanofibers: Immobilization on the electrospun mat’s surface and encapsulation in the fiber structure. The nanofibers obtained by Doxy encapsulation were characterized using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) and differential thermal analyses (DTA) and scanning electron microscopy (SEM). The adsorption properties of pure PLA and PLA-HAP nanofibers were investigated for solutions with different Doxy concentrations (3, 7 and 12 wt%). Moreover, the desorption properties of the active substance were tested in two different fluids, simulated body fluid (SBF) and phosphate buffer solution (PBS), to evidence the drug release properties. In vitro drug release studies were performed and different drug release kinetics were assessed to confirm the use of these nanofiber materials as efficient drug delivery vehicles. The obtained results indicate that the PLA-HAP-Doxy is a promising system for biomedical applications, the samples with 3 and 7 wt% of Doxy-loaded PLA-HAP nanofibers prepared by physical adsorption are the most acceptable membranes to provide prolonged release in PBS/SBF rather than an immediate release of Doxy.
Highlights
The electrospinning procedure is a frequently used technique in biomedicine [1], bone regeneration [2] and dental fields [3], with promising applications which include drug delivery carriers, tissue engineering and wound dressing [4]
A novel membrane was developed from hydrophobic polylactic acid (PLA) polymer and biocompatible HAP, as a potential drug delivery vehicle for the prolonged release of Doxy
Mathematical models describing drug release were used to explain the release profiles and to investigate the release mechanism for both Doxy-loaded HAP samples encapsulated in PLA fibers and Doxy-loaded PLA/HAP fibers prepared by physical adsorption
Summary
The electrospinning procedure is a frequently used technique in biomedicine [1], bone regeneration [2] and dental fields [3], with promising applications which include drug delivery carriers, tissue engineering and wound dressing [4]. The prevalence of this method is due to the excellent properties of the nanofibers. The most studied area of nanofiber-based composites is in the design of drug delivery and controlled release systems. The method allows both the efficient binding of active anti-inflammatory drugs and antibiotics and the immobilization of enzymes and macromolecules
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
