Abstract
Curcumin as a natural medicinal agent has been proved to kill cancer cells effectively. However, its biomedical applications have been hindered owing to its poor bioavailability. Many nanoparticulate systems have been introduced to overcome this problem. Among this types polymeric-based nanoparticles which exhibit unique properties allowing their use as a efficient drug carrier. Developing a polymeric- blend nanoparticles will offer a promising nanocarrier with excellent biocompatibility, biodegradability and low immunogencity.
 In this study, curcumin nano-vehicle has been made up by combining dextren sulfate and chitosan (DSCSNPs). DSCSNPs have been characterized using different techniques. Transmission electron microscopy (TEM) which revealed the spherical, smooth surface of the nano-formulation. Dynamic light scattering (DLS) for measuring DSCSNPs hydrodynamic- diameter. Zeta potential measurements showed nanoparticles high stability. Fourier transform infrared spectroscopy (FTIR) confirmed successful combination between the two polymers and curcumin loading on naoparticles surface. Curcumin release profile out of DSCSNPs showed high drug release in tumor acidic microenvironment. In vitro cytotoxicity measurements demonstrated that curcumin loaded polymeric nanoparticles (DSCSNPs-Cur) have high therapeutic efficacy against colon (HCT-116) and breast (MCF-7) cancer cells compared with free curcumin. DSCSNPs as a combined biopolymers is an excellent candidate for improving curcumin bioavailability allowing its use as anticancer agent.
Highlights
Curcumin is a nutraceutical bioactive compound that exhibit an activity against different cancer types including skin, oral cavity, mammary glands, digestive system organs, [1,2,3]
The current study aims to prepare dextran sulphate- chitosan nanoparticles (DSCSNPs) as a promising nanocarrier that characterized by its high biocompatability and biodegradability, in addition to excellent stability in different pHs
The prepared dextran sulphate-chitosan nanoparticles (DSCSNPs) exhibit high biocompatibility and biodegradability allowing its use in pharmaceutical products as an effective capsule for controlled drug release
Summary
Curcumin is a nutraceutical bioactive compound that exhibit an activity against different cancer types including skin, oral cavity, mammary glands, digestive system organs (esophagus, colon, liver,...etc), [1,2,3]. Despite of its potential activity against cancers, curcumin bioavailability is low owing to its: hydrophobic nature [11], lack of tissue absorption, rapid metabolism and systemic clearance [12,13]. Such reduced bioavailability of curcumin hinder its therapeutic efficacy [14]. The current study aims to prepare dextran sulphate- chitosan nanoparticles (DSCSNPs) as a promising nanocarrier that characterized by its high biocompatability and biodegradability, in addition to excellent stability in different pHs. DSCSNPs as a nanocarrier for curcumin is expected to greatly improve its bioavailability and enhance its therapeutic efficacy against cancer
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