Abstract
Calcium phosphate cements (CPCs) have been widely used as bone substitute materials. However, their degradation property is insufficient to stimulate bone healing in large bone defects, besides, the poor initial mechanical strength limits their application to non-load bearing areas. In this study, to overcome the drawbacks of CPCs, magnesium phosphate cements (MPCs) characterized by high initial strength and relatively rapid degradation were combined with CPCs to develop novel calcium-magnesium phosphate cements (CMPCs). The morphology of the CPC sample consisted of needle-like crystals, whereas the interlinked hemispherical globules were observed for the CMPCs. The handling and mechanical characteristics of the samples as well as their degradation behavior under in vitro condition were investigated. Results showed that the CMPCs exhibited shorter setting time and higher compressive strength than the CPC. In addition, CMPCs showed significatnly improved degradability compared to the CPC in Tris-HCl buffer solution.
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