Abstract
The combination of biomimetic scaffolds and nano drug delivery has been proposed to be an effective solution to the inherent limitations of the former in regulating cell behavior and bone tissue regeneration. Herein, a series of three-dimensional (3D) aspirin-loaded polylactic acid/graphene oxide (PLA/GO) porous biomimetic nanofibrous composite scaffolds (PBNCSs) was successfully prepared by phase separation. Results showed that the PLA/GO scaffolds have a biomimetic nanofibrous porous structure and a thin GO film covering the PLA nanofibers, which endows the latter with significantly improved hydrophilicity. Close interactions were noted in the GO–PLA interface. GO reduced the mechanical properties of the composite scaffolds but increased their thermal stability. The water absorption rate increased from 12.5% to 206.81% as the GO content increased from 0 to 5%. Addition of GO improved the deposition rate and amount of hydroxyapatite on the scaffolds. Overall, the PLA/GO PBNCSs demonstrated good cytocompatibility and sustained-release performance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
