Abstract
The purpose of this work is to improve the cytocompatibility and corrosion resistance of magnesium alloy in the hope of preparing a biodegradable medical material. The aminated hydroxyethyl cellulose-induced biomimetic hydroxyapatite coating was successfully prepared on AZ31 magnesium alloy surface with a sol-gel spin coating method and biomimetic mineralization. Potentiodynamic polarization tests and electrochemical impedance spectroscopy showed that the hydroxyapatite/aminated hydroxyethyl cellulose (HA/AHEC) coating can greatly improve the corrosion resistance of AZ31 magnesium alloy and reduce the degradation speed in simulated body fluid (SBF). The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide] method and cell morphology observation results showed that the HA/AHEC coating on AZ31 magnesium alloy has excellent cytocompatibility and biological activity.
Highlights
Metals and their alloys are widely used in dentistry, orthopedics and cardiovascular medicine because of their good mechanical properties and good biocompatibility as implant materials [1,2,3,4].Magnesium is a necessary element to human nutrition, and some scholars believe that magnesium and magnesium alloys are suitable as a biodegradable implant material [5,6]
These results show that the coating on the aminated hydroxyl ethyl cellulose (AHEC)/AZ31 are not observed in the hydroxyapatite/aminated hydroxyethyl cellulose (HA/AHEC)/AZ31
A homogeneous HA/AHEC double coating with AHEC as the nucleation center is successfully prepared on AZ31 magnesium alloy surface using a sol-gel spin coating method and biomimetic mineralization
Summary
Magnesium is a necessary element to human nutrition, and some scholars believe that magnesium and magnesium alloys are suitable as a biodegradable implant material [5,6]. They have excellent mechanical strength and good anti-electromagnetic wave properties [7,8]. Magnesium alloys suffer from a low corrosion resistance in chloride solutions, and this greatly limits their applications in biomedical fields [9,10]. To guarantee the excellent mechanical properties of magnesium alloys, some scholars have performed the surface treatment of magnesium alloys by using osteo-integration or osteo-conductive performance of biomaterials to increase the corrosion resistance of magnesium alloys [11]
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