Abstract
A kind of degradable magnesium phosphate bone cement (MPBC) was fabricated by using the mixed powders of magnesium oxide (MgO), potassium dihydrogen phosphate (KH2PO4) and calcium dihydrogen phosphate (Ca(H2PO4)2.H2O). As MgKPO4, the main product of MgO and KH2PO4 was alkaline, the Ca(H2PO4)2.H2O was added to neutralize the alkali of the system. And the effects of Ca(H2PO4)2.H2O on the performance of MPBC were discussed. The results showed that the adding of Ca(H2PO4)2.H2O extended the setting time, which was about 6 min to 18 min. The compressive strength increased first and then decreased, and maximum value reached 31.2 MPa after setting for 24 h without any additional pressure. The MPBC was degradable in Tris–HCl solution, and the extracts of the cytotoxicity assay showed that the MPBC had good biocompatibility, indicating that the MPBC had good biodegradable and biocompatible properties.
Highlights
Magnesium phosphate bone cement (MPBC) has attracted much attention in bone regeneration for its high initial strength, fast setting time and moderate degradation rate compared with calcium phosphate bone cement (CMPC) [1,2,3]
MPBC composed of powders and cement liquid, and the powders were composed of magnesium oxide (MgO), KH2PO4 and Ca(H2PO4)2.H2O
The diffraction peak intensity of MgO decreased, while the diffraction peak intensity of KMgPO4 increased with the increase of KH2PO4, meaning that MgO was totally transformed into KMgPO4
Summary
Magnesium phosphate bone cement (MPBC) has attracted much attention in bone regeneration for its high initial strength, fast setting time and moderate degradation rate compared with calcium phosphate bone cement (CMPC) [1,2,3]. When compared to NH4H2PO4, KH2PO4 has smaller dissociation constant and lower solubility, resulted in controlling the reaction rate easier, and does not produce unpleasant odour when reacts with water [15,16], and the final product is magnesium potassium phosphate hexahydrate (MgKPO4Á6H2O), which is isostructural with struvite and a naturally existing mineral known as struvite-(K) [17,18]. The influences of Ca(H2PO4) on setting time, compressive strength, degradation rate and biocompatibility are discussed
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