Abstract
A series of tetradentate N2O2 Schiff-base compounds were synthesized by condensing one equivalence of1,3-diaminopropane derivatives along with four groups of two equivalences of salicylaldehyde derivatives. Chemical characteristics of these compounds were analyzed by using proton nuclear magnetic resonance(1H-NMR)and Fourier transform infrared spectroscopy(FTIR).These Schiff-base compounds were labeled with tracer-level 99mTcO(superscript-)4 to proceed with complexing informing 99mTc-complex.The complexing yields and lipophilicities were evaluated by solvent extraction technique. The complexing yields ranged from 76.9% to97.5% for the eight 99mTc-complexes in pH 8～9 buffer. The complexes studied varied in lipophilicity from log P=1.10 to log P=2.68,where P was the octanol/water partition coefficient. Biodistributions of the eight 99mTc-complexes in Wistar rats were similar. Biodistributiontests demonstrated that the metabolic pathway of 99mTc-complexes on Wistar rats was via hepatobiliary duct; however, low clearance of activities is through kidneys.
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