Abstract
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.
Highlights
Published: 1 July 2021The skin, one of the largest and important organs, is the natural barrier of the human body [1]
−1 was associated with the variable-angle vibration of -NH2, confirming that adipic dihydrazide (ADH) was cm was successfully grafted with hyaluronic acid (HA) [28]
An Oxidized dextran (ODex)/HA-ADH/HACC hydrogel with Ag nanoparticles (AgNPs) grown in situ were prepared for burn wound treating
Summary
The skin, one of the largest and important organs, is the natural barrier of the human body [1]. Studies investigating the application of the synergistic antimicrobial hydrogels with inherent antimicrobial activity and antibacterial agents in wound healing is limited. Such antibacterial hydrogel will be of great significance to the development of burn wound dressing. Previous studies revealed that chitosan-based hydrogels could be used in wound healing by reason of its inherent antibacterial properties [17,18]. It can absorb exudates and prevent the microorganisms of the external environment invading the wound through forming a thin barrier [19].
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