Abstract
ABSTRACTChitosan is stepwise treated with periodic acid, urea and formaldehyde and then introduced hydroximethyl groups reacted with doxorubicin. The conjugate obtained AX1 is fully soluble in dimethylformamide in contrast to the free chitosan. The appearance of new bands at 1540 cm−1 and 3440 cm−1 of the conjugate leads to the suggestion that the NH2 group of antibiotic has involved in bond formation. The numbers of doxorubicin residues introduced in chitosan are 402.3 or 25.2%. The antitumor activity has studied against Bacillus subtilis AT6633.Compared to unmodified doxorubicin the activity of the conjugate was 89.4%. The antitumor activity of the conjugate against P 388 mice leukemia was maximaly at 8.0 mg/kg and T/C was 315.6% in comparation 167.6% at dose 0.25 mg/kg.
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