Abstract
3-Substituted 5-methyl-1-{p-[(3, 5-dimethyl)pyrazol-1-yl]-, 5-methyl-1-{p-[(5-methyl-3-carboxy)pyrazol-1-yl]-, 1-{p-[(3-methyl-5-phenyl)pyrazol-1-yl]-, and 1-{p-[(3-methyl-4-bromo-5-phenyl)pyrazol-1-yl]benzenesulfonyl}-2-thiohydantoin and their 5-methyl-2-thiohydantoin and 5, 6-dihydro-4(3H)-oxo-2(1H)-pyrimidinethione derivatives were prepared for evaluation as hypoglycemic agents. Biological testing showed that some of these compounds possessed antidiabetic activity.
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