Abstract
4-Iodoantipyrine was prepared from antipyrine according to the reaction equation: 3C 11 H 12 N 2 O+2KI+KIO 3 +3HCl→3C 11 H 11 N 2 OI+3KCl+3H 2 O The product was separated from the reaction mixture and purified by recrystallization. The iodoantipyrine was labeled with I 131 by means of an exchange reaction with NaI 131 . It was separated from the unbound radioactivity by anion exchange chromatography. The purity of the product was determined by cellulose thin layer chromatography using ethanol-chloroform-water (45:45:10) as the solvent system. The purity of the 4-iodoantipyrine-I 131 decreased with time due to a splitting off of the I 131 atom and subsequent formation of NaI 131 . This spontaneous deiodination was best minimized by storage in methanol at low temperatures.
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