Abstract
In an assessment of risk for differentiated thyroid cancer (DTC) in individuals with human papillary thyroid cancer (PTC) and thyroid nodules a cohort prospective study was undertaken to establish the significance of preoperative thyroid-stimulating hormone (TSH) levels. Confirmed histologically PTC cases in one tertiary care center, and matched healthy individuals were tested for TSH, T3, T4 and T4 free total. The ORs and 95% confidence intervals have been calculated using conditional logistic regression models (CI). The blood TSH levels were related to the higher risk of PTC for men (OR,0,09; 95% Ci, 04-0,21, 95% CI and women) compared with the middle tertile of the TSH levels in the normal range (OR,0,07; 95 percent CI, 0,04-0,1). Over the normal range of TSH levels, an elevated PTC risks were connected amongst women (OR 0,09; 95% CI, 0,04-0,21) but not amongst men (OR,0,07; 95% CI, 0,04-0,1). With an increase in TSH level in the normal range between men and women, the risk for PTC reduced (Ptrend=0.041 and 0.0001). The risk of PTC related to TSH levels has been dramatically elevated above the normal range for men and TSH values below the normal range for women.
Highlights
Thyroid cancer is one of the most common endocrine system malignancies, accounting for around 1% of all neoplasms in China, with an annual incidence of up to 20 per 100,000 people
We found that serum thyroid-stimulating hormone (TSH) levels below the normal range were related to a high papillary thyroid cancer (PTC) risk for males but not females in this large-scale case-control study using prediagnostic serum measurements and having adequate gender strength to stratify
An elevated risk of PTC in women was associated with TSH levels above the normal range
Summary
Thyroid cancer is one of the most common endocrine system malignancies, accounting for around 1% of all neoplasms in China, with an annual incidence of up to 20 per 100,000 people. Thyroid cancer is more common in high-income areas than in middle- or lowincome areas, and the incidence is much higher in highincome areas than in middle- or low-income areas [1]. Thyroid cancer is the most common of all endocrine cancers, and its incidence is rising faster than any other cancer in both men and women 1. There is little understanding of the causative mechanisms driving thyroid cancer. Higher body weight and height have recently been established as risk factors for thyroid cancer [5]
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