Preoperative sST2 levels relate to myocardial remodeling and cardiac function improvement after cardiac valve surgery.

Abstract

We aim to investigate the correlation between preoperative soluble suppression of tumourigenicity 2 (sST2) and postoperative myocardial remodelling and cardiac function in patients with valvular heart disease. This retrospective study included patients who underwent heart valve surgery at the General Hospital of Northern Theatre Command from July 2019 to June 2020. Preoperative, early postoperative, and 1-month postoperative cardiac ultrasound data were collected. Multivariable linear regression was used to analyse the factors associated with preoperative sST2 and postoperative cardiac function parameters. A receiver operator characteristic curve analysis was used to analyse the predictive value of sST2 for left ventricular ejection fraction (LVEF) reduction at 1month after surgery. This study included 156 patients. Left ventricular end-systolic volume (b=0.125, P=0.004), atrial fibrillation (b=7.933, P=0.003), and coronary artery disease (b=5.826, P=0.043) were correlated with the preoperative sST2 levels. Preoperative sST2 was independently associated with early postoperative left ventricular end-systolic volume (b=-0.136, P=0.035), left ventricular end-diastolic volume (b=-0.225, P=0.036), and LVEF (b=0.056, P=0.008). At 1month after surgery, LVEF (r=-0.234, P=0.023) and reduction in LVEF (r=-0.316, P=0.002) were negatively correlated with preoperative sST2. The area under the receiver operator characteristic curve of preoperative sST2 in predicting LVEF reduction at 1month was 0.646, with a sensitivity of 0.357 and a specificity of 0.918. Preoperative sST2 levels are related to early postoperative myocardial remodelling and have a predictive value for the improvement of cardiac function 1month after surgery.