Abstract
We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) levels in non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP). We enrolled 41 NSCLC patients with IP who have undergone curative surgery. Prognostic significance of serum KL-6 and SP-D levels was examined. We found a significant relationship between serum KL-6 and SP-D levels in NSCLC patients with IP. However, the 5-year survival of patients with high serum KL-6 level was poor, whereas serum SP-D level was not related to patients’ survival. Univariate analysis revealed that there was a trend towards an association between serum KL-6 level and patients’ prognosis but this did not reach statistical significance. This might be due to small number of study patients. In conclusion, there is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of IP.
Highlights
We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) levels in non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP)
We found a significant relationship between serum KL-6 and SP-D levels in NSCLC patients with IP
There is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of IP
Summary
Some previous studies showed that serum KL-6 level is useful for predicting survival of non-small cell lung cancer (NSCLC) patients who have undergone curative surgery [6] [7]. It has not been known whether NSCLC patients with IP might have higher serum levels of KL-6. Only a few study examined the prognostic significance of serum KL-6 level in NSCLC patients with IP [8] [9]. Miyazaki et al [8] reported the prognostic significance of serum KL-6 levels in lung cancer patients with or without IP. Our previous study showed the similar findings [9], but the number of patient with IP was very small (only 14 patients)
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