Abstract
Aim: The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis. The purpose of this study was to investigate the preoperative serum levels of IL-6 in gastric carcinoma with lymph node metastasis, and to correlate them with disease status. Method: A total of 100 patients who underwent gastrectomy were enrolled in this study. Serum levels of IL-6 were assessed enzyme linked immunosorbent assay (ELISA). Histological findings included tumor size, depth of tumor invasion, lymph node (LN) metastasis, and TNM stage. Result:Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 levels were correlated with invasion depth (p<0.001), LN metastasis (p<0.001), and TNM stage. The presence of peritoneal seeding metastasis is associated with IL-6 levels (p<0.001). Conclusion: Preoperative serum IL-6 levels might be markers of tumor invasion, LN metastasis, and TNM stage. These results suggest that IL-6 levels are potential molecular markers that predict lymphatic involvement in gastric carcinoma.
Highlights
Gastric cancer is one of the leading causes of death in the world
Preoperative serum IL-6 levels might be markers of tumor invasion, lymph node (LN) metastasis, and TNM stage. These results suggest that IL-6 levels are potential molecular markers that predict lymphatic involvement in gastric carcinoma
The largely purpose of this study was to determine the relationship between serum IL-6 and lymphangiogenesis and prognosis in gastric cancer patients
Summary
Gastric cancer is one of the leading causes of death in the world. Metastasis to the regional lymph node is an indicator of tumor progression as well as an important prognostic factor in gastric cancer. Recent evidence suggests that tumor lymphangiogenesis promotes lymphatic metastasis [1,2,3,4]. Little is known about the mechanism of lymphangiogenesis in gastric carcinoma. Interleukin-6 (IL-6) is a multi-poietic cytokine that induces the growth and differentiation of immune cells, the expression of other cytokines, and acute-phase protein synthesis. IL-6 marks various effects on cancer cells [5, 6]
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