Abstract
Colorectal cancer is the third most common cancer in incidence and the leading cause of death among males and females. Colorectal cancer liver metastatic disease (CRCLM) is the most common cause of death in these patients. Liver resection is the best treatment modality to be offered for CRCLM patients; however, most patients are not good candidates for liver resection. The scope of this review is to discuss the preoperative selection process and the optimization methods that can be used to maximize the eligibility for liver resection in CRCLM. The advancement in perioperative management and the engagement of the multidisciplinary methodology in treating patients with colorectal liver metastasis resulted in improving the survival rates, decreasing perioperative complications, and expanding the criteria for liver resection for CRCLM patients. The management of colorectal cancer liver metastasis is evolving. Patient selection and perioperative optimization play an essential role to offer a safer liver resection with a reasonable oncologic outcome; personalization of therapy is the next evolution in treating CRCLM patients.
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