Abstract
The addition of chemotherapy to preoperative radiotherapy (RT) has been established as the standard of care for patients with cT3-4 rectal cancer. As an alternative strategy, we reported previously in a phase II study a limited toxicity and high 5-year local control rate with preoperative image-guided and intensity-modulated RT (IG-IMRT) with a simultaneous integrated boost (SIB), without concomitant chemotherapy. Here, we compared this strategy to chemoRT in an international multicentric randomized trial (NCT 01224392).
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