Abstract
Objective: To investigate the prognostic values of preoperative prognostic nutritional index (PNI) in patients with lower-grade gliomas. Methods: In the study, 379 patients with pathological diagnosis of lower-grade gliomas were enrolledwhich were confirmed in The First Affiliated Hospital of Zhengzhou University (2011-02 to 2016-05). Kaplan-Meier method was used to calculate the survival rates. log-rank was used to calculate the differences in group. Cox regression model was used to conduct multivariate analysis. Results: The cutoff value of PNI was 46.70. The median survival time of PNI≤47.80 and PNI>47.80 subgroups were 46.76 and 67.37 months with statistical significance (P<0.001). High PNI predicted a better survival rate. Multivariate survival analysis demonstrated that low PNI was an independent risk factor to evaluate the prognosis of glioma patients. In lower-grade gliomas, high PNI predicted better survivals in TERT mutation only (P=0.003) and triple-negative group (P=0.007). Conclusion: In lower-grade gliomas, low PNI predicts worse survivals and PNI have differential prognostic significances in molecular groups of lower-grade gliomas.
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