Abstract
BackgroundPancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein invasion in patients with pancreatic head cancer.Study designData of patients with carcinoma head of pancreas and suspected peripancreatic invasion (n = 247) who underwent pancreatic resection with venous reconstruction between January 2012 and January 2017 at four academic institutions were retrospectively analyzed. Univariate and multivariate analyses were used to identify independent risk factors for vein invasion from among demographic, biological, conditional host-related, and anatomical data. A predictive nomogram was constructed based on the identified independent risk factors.ResultsThe nomogram was constructed using data from 181 patients while the validation cohort consisted of 66 patients. Length of tumor contact (P = 0.031), circumferential vein involvement (P = 0.048), and venous contour abnormalities (P = 0.001) were independent predictors of venous invasion. The C-index of the model in predicting venous invasion was 0.963 for the external validation cohort. Patients could be assigned into low- (< 50%), intermediate- (50–90%), and high-risk (> 90%) groups based on the nomogram to facilitate personalized management.ConclusionsVein invasion by pancreatic head cancer is mainly associated with anatomical factors. The nomogram for prediction of vein invasion was found to be practicable.
Highlights
Pancreatic cancer is a lethal disease with high morbidity and dismal prognosis [1, 2]
The nomogram was constructed using data from 181 patients while the validation cohort consisted of 66 patients
Patients could be assigned into low- (< 50%), intermediate- (50–90%), and high-risk (> 90%) groups based on the nomogram to facilitate personalized management
Summary
Pancreatic cancer is a lethal disease with high morbidity and dismal prognosis [1, 2]. In contrast to the steady improvement in survival rates in other cancers, the survival rate in pancreatic cancer remains low at 8%. This poor survival rate is partly because more than one-half of cases are diagnosed at an advanced stage, when the 5-year survival is only 3% [2]. A meta-analysis as reported that 20% of pancreatic cancer patients are eligible for one-stage resection by imaging [3], 14–30% of these patients will be found to be unsuitable. Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein invasion in patients with pancreatic head cancer
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