Preoperative intravenous flurbiprofen reduces tracheal extubation-induced adverse effects

Abstract

Objective To assess whether preoperative intravenous administration of flurbiprofen, a non-steroidal anti-inflammatory drug, reduces tracheal extubation-induced adverse effects. Methods Sixty patients undergoing lumbar vertebra fixation with general anesthesia were randomly assigned to one of three groups (n＝20). Placebo (group C and group Post ) or flurbiprofen (group Pre ) was injected 30 min before surgery; and placebo (group C and group Pre) or flurbiprofen (group Post) was injected 30 min before surgery termination. Results Groups were comparable for age, weight, sex, operation duration, extubation time and intraoperative blood loss.The incidence of postoperative throatache in PRE group and POST group was respectively 2/25、6/25. RS in PRE group and POST group was respectively 0.51 ±0.31、1.52±0.51. The incidence of postoperative throatache and RS in control group was respectively 14/25、2.82±0.41. PRE group and POST group were apparently lower than control group(P＜ 0.05 ). There was significant defference in throat ache and RS between PRE group and POST group(P ＜ 0.05 ). BCS of PRE group and POST group was respectively 4.73±0.50、3.00±0. RSS of PRE group and POST group was respectively2.16±0.26、2.06±0.21. BCS and RSS of control group were respectively 2.21 ±0.42、1.46±0.25.RSS and BCS of PRE group and POST group were obviously higher than control group (P＜ 0.05 ). There was obviously defference of BCS between PRE group and POST group. Nausea and vomit were not found in three group. The increase values of cortisol and glucose of PRE group and POST group were lower than control group (P＜ 0.05). There was also remarkable defference between PRE group and POST group. Conclusion Pre-operative flurbiprofen axetil analgesia reduces tracheal extubation-induced adverse effect and improves recovery quality. Key words: Flurbiprofen; Preemptive analgesia; Extubation-induced side effects