Abstract
Background Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging. We have shown that preoperative fasting in young-lean C57BL6 male mice protects against renal IRI [1]. Since human patients are usually older and suffer from (co)morbidities, we investigated the effects of preoperative fasting on OS induced by renal IRI in both female and male aged-corpulent mice in a F1 -FVB/C57BL6hybrid background.
Highlights
Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging
We have shown that preoperative fasting in young-lean C57BL6 male mice protects against renal IRI [1]
Since human patients are usually older and suffer frommorbidities, we investigated the effects of preoperative fasting on OS induced by renal IRI in both female and male aged-corpulent mice in a F1 -FVB/C57BL6hybrid background
Summary
Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging. We have shown that preoperative fasting in young-lean C57BL6 male mice protects against renal IRI [1]. Since human patients are usually older and suffer from (co)morbidities, we investigated the effects of preoperative fasting on OS induced by renal IRI in both female and male aged-corpulent mice in a F1 -FVB/C57BL6hybrid background
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