Abstract
BackgroundThe objective of this study is to evaluate the effectiveness of preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by carbon nanoparticle tattooing in laparoscopic colorectal cancer surgery.MethodsFrom January 2013 to December 2014, 54 patients with colorectal cancer were recruited and divided into experimental (n = 27) and control (n = 27) groups. The patients in the experimental group were localized preoperatively by endoscopic carbon nanoparticle tattooing, whereas patients in the control group were not tattooed.ResultsAll injection sites in the experimental group were visible to surgeons. No abdominal pain, fever, diarrhea, and other symptoms of infection were found in the experimental group. The time for detecting the tumor (2.71 ± 2.13 min versus 6.91 ± 5.16 min, p < 0.001), operation time (151.22 ± 30.66 min versus 170.26 ± 33.13 min, p = 0.033), and blood loss during the operation (125.04 ± 29.48 mL versus 147.52 ± 34.35 mL, p = 0.013) were lower in the experimental group than in the control group. Average numbers of dissected lymph nodes in the experimental group exceeded those in the control group (14.41 ± 3.32 versus 8.96 ± 2.90, p < 0.001), and the rate of dissected lymph nodes ≥12 was higher in the experimental group than in the control group (70.37 versus 37.04 %, p < 0.001). Moreover, no difference in postoperative complications was found between the two groups.ConclusionsTattooing colorectal cancer with carbon nanoparticles in laparoscopic colorectal cancer surgery is safe and useful both in localization and lymph node tracing.
Highlights
The objective of this study is to evaluate the effectiveness of preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by carbon nanoparticle tattooing in laparoscopic colorectal cancer surgery
Clinical results of preoperative colonoscopic localization using carbon nanoparticles Tumors in all patients in the experimental group were localized by preoperative colonoscopic tattooing with carbon nanoparticles
One patient in the experimental group underwent surgery following carbon nanoparticle tattooing after 1.5 months because of personal reasons
Summary
The objective of this study is to evaluate the effectiveness of preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by carbon nanoparticle tattooing in laparoscopic colorectal cancer surgery. Colorectal cancer is the third most commonly diagnosed cancer in males and is the second most commonly diagnosed cancer in females. This disease is among the main causes of cancer death in both males and females [1]. As the organs could only be manipulated with the use of an instrument and owing to the lack of hand feeling during laparoscopic colorectal cancer surgery, precise localization of the tumor by surgeons is difficult, especially in the absence of obvious lesion changes or marks on the serosal surface [6]. According to the NCCN guideline [7], preoperative colonoscopic localization is recommended for small lesions in laparoscopic-assisted colectomy
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