Abstract
As is now known, MH is an autosomal dominant disorder of skeletal muscle calcium dysregulation. 8 It is a myopathy, usually subclinical, but after triggering by anesthetic vapours or succinylcholine, an acute loss of intracellular calcium control causes hypermetabolism, rhabdomyolysis, multi-organ failure and death unless immediately treated with dantrolene. 9 Although it is only anesthetics that can trigger an acute MH reaction they are inconsistent in their ability to trigger. Thus, a MH susceptible patient can trigger on first exposure or only after the fifth or sixth GA unlike the PORCINE STRESS SYNDROME in pigs where any stress such as separation, shipping, weaning, fighting, coitus or preparation for slaughter could lead to an acute MH episode. 10
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