Abstract
We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.
Highlights
Granular cell tumors are uncommon generally benign soft tissue neoplasms first described in 1926 by Abrikossoff [1]
We describe the first case report of a preoperative, definitive diagnosis of a mediastinal granular cell tumor diagnosed on a cytologic endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) specimen
Confirmatory ancillary studies including immunohistochemistry and electron microscopy were performed on the cell block obtained via EUS-FNA
Summary
Granular cell tumors are uncommon generally benign soft tissue neoplasms first described in 1926 by Abrikossoff [1]. Granular cell tumors commonly occur in the tongue, gastrointestinal tract, mediastinum, skin, breast, as well as other sites [2,3,4,5]. Mediastinal granular cell tumors are, exceptionally rare. The diagnosis of mediastinal granular cell tumors has been made on histologic material. Cytologic material was available for only one of the previously described mediastinal granular cell tumors [6]. A definitive diagnosis was not rendered based upon the FNA specimen. We describe the first case report of a preoperative, definitive diagnosis of a mediastinal granular cell tumor diagnosed on a cytologic EUS-FNA specimen. Confirmatory ancillary studies including immunohistochemistry and electron microscopy were performed on the cell block obtained via EUS-FNA
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