Abstract
Cryopreservation has been applied in the replantation of limbs with a minimal amount of muscle tissue replanted. And small composite tissues have also been reported to be successfully replanted by preoperative cryopreservation. In this study, we aimed to study the effect of preoperative cryopreservation on digital survival after digit replantation. Accordingly, we collected and compared the demographic and clinicopathological characteristics of patients with digit injury of patients, and we observed no significant difference between the NT and CP patients of digital injury. We also investigated the records of successful digit replantation and other parameters which influenced the odds of digital survival of all recruited patients. Accordingly, we found that the number of survived digits was remarkably increased in patients in the CP group compared with that in patients in the NT group. And the number of patients requiring blood transfusion and the mean length of hospital stay were notably decreased in the CP group. And compared with other patient characteristics, the mechanism of injury (blade, crush, or avulsion) showed a remarkable difference between the two groups of digital failure. Moreover, we analyzed the correlations between patient characteristics and the odds of digit survival and found that compared with other basic characteristics of patients and their injury, the preservation temperature, especially cryopreservation, could significantly promote digital survival after replantation.
Highlights
Failure of a revascularized or replanted finger can cause a damaging outcome
By comparing the records of successful digit replantation and other parameters which possibly influenced the odds of digital survival, we aimed to investigate the effect of preoperative cryopreservation on digital survival after digit replantation
In addition to the preservation temperature under which the fingers of the patients were stored before the replantation procedure was carried out, the injury parameters of the injured digits were further calculated for the patients in the Normal temperature CP (NT) and CP groups
Summary
The reasons of failed digital replantation can be many, the pinpointing of contributory factors may help to take full advantage of successful digital replantation. Factors shown to considerably affect the rate of successful digital replantation consist of injury mechanism (avulsion or crushed digit), severity of injury, history of smoking, and history of diabetes mellitus [1–4]. Thermoregulation refers to the capability to regulate cutaneous blood circulation in reaction to adjustments in the temperature, allowing warm-blooded tissues to survive in different environments. The skin layer is consisted of a vessel bed in the volar as well as plantar surfaces of the feet and hands, for example, to help with thermoregulation. The typical activity of thermoregulatory vessel can maintain a stable body temperature without impairing the flow of nutrition to the tissues
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Computational and Mathematical Methods in Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
