Preoperative correction of a platelet functional disorder.

Abstract

Letters1 June 1973Preoperative Correction of a Platelet Functional DisorderHARRY R. LOCKE, M.D., W. E. HATHAWAY, M.D., FREDERIC FEILER, M.D., DONALD L. DAWSON, M.D.HARRY R. LOCKE, M.D.Search for more papers by this author, W. E. HATHAWAY, M.D.Search for more papers by this author, FREDERIC FEILER, M.D.Search for more papers by this author, DONALD L. DAWSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since 1967 several cases of a mild to moderately severe bleeding disorder associated with a platelet functional defect have been described (1-5). This disorder has been called "failure to release ADP [adenosine 5′-diphosphate]" and is characterized by normal coagulation studies, normal platelet counts, variable prolongation of the bleeding time, poor platelet retention in glass-bead filters (platelet adhesivity), and decreased aggregation of platelets by collagen and epinephrine. Platelet aggregation by exogenous adenosine 5′-diphosphate is usually normal.Our report describes an additional case and documents correction of the defect by platelet transfusions during a surgical procedure.The patient, a...