Preoperative blood counts predict overall survival in patients undergoing surgical removal of brain metastasis

Abstract

The prognosis for patients with cancer with brain metastasis (BM) requiring surgical removal is quite limited. Preoperative prognostic factors can provide meaningful information to surgeons, oncologists, and patients. This study evaluated the preoperative blood counts in patients with BM who were treated with surgical removal. Between January 2011 and November 2021, 221 consecutive surgeries were conducted on 198 patients with BM. Among the 198 patients, 188 patients with sufficient blood test data and follow-up were analyzed in this study. The tumors originated from the lungs (n = 102, 54.3%), colon (n = 26, 13.3%), breast (n = 13, 6.9%), kidney (n = 8, 4.3%), stomach (n = 6, 3.2%), and others (n = 33, 17.6%). The blood test data included neutrophils, lymphocytes, monocytes, eosinophils, basophils, red blood cell count, hemoglobin, and albumin. The median follow-up and median survival times were both 11 months (range: 0-139 months). Higher neutrophil-lymphocyte ratio (NLR) ≥ 3.17, platelet-lymphocyte ratio (PLR) ≥112.7, systemic immune-inflammation index (SII) ≥594.4, systemic inflammation response index (SIRI) ≥1.25 were unfavorable predictors of prognosis for the patients treated with surgical removal for BM (p < 0.001). Furthermore, lower lymphocyte-monocyte ratio (LMR) <2.33 and prognostic nutritional index (PNI) <48.5 were unfavorable predictors. Simple, less expensive, routinely ordered preoperative blood count assessments, such as the NLR, PLR, LMR, SII, SIRI, and PNI, can predict the overall survival of patients treated with surgical removal for BM.