Preoperative and intraoperative predictors of deep venous thrombosis in adult patients undergoing craniotomy for brain tumors: A Chinese single-center, retrospective study

Abstract

PurposeBrain tumor resection by craniotomy is associated with a high risk of deep vein thrombosis (DVT). This study evaluated the incidence and preoperative and intraoperative risk factors for DVT within 30 days of surgery. MethodsThe analysis included: 1) basic clinical variables (patient age, sex, body mass index [BMI], tumor location, and tumor histology); 2) blood test results before operation, such as leukocytes, platelets, and coagulation parameters; and 3) surgical factors (total amount of blood lost, anesthesia mode, and surgery duration). ResultsOf the 1670 patients, 206 (12.34%) had DVT and nine (0.54%) had both DVT and pulmonary embolism (PE) after surgery. Preoperative and intraoperative factors independently associated with DVT/PE were: older age 46–55 years (odds ratio [OR]: 2.87; 95% confidence interval [CI]: 1.83–4.50; P < 0.001), age 56–65 years (OR: 5.24; 95% CI: 3.27–8.40; P < 0.001), age > 65 years (OR: 6.00; 95% CI: 3.45–10.45; P < 0.001), BMI (OR: 1.03; 95% CI: 1.00–1.05; P = 0.029), activated partial thromboplastin time [APTT] (OR: 0.91; 95% CI: 0.86–0.95; P = 0.000), D-dimer (OR: 1.69; 95% CI: 1.23–2.34; P = 0.001), high-grade glioma (OR: 2.09; 95% CI: 1.28–3.40; P = 0.003), glio-neuronal (OR: 3.30; 95% CI: 1.28–8.47; P = 0.013), craniopharyngioma (OR: 2.16; 95% CI: 1.13–4.10; P = 0.019), and surgery duration (OR: 1.82; 95% CI: 1.27–2.60; P = 0.001). ConclusionsOlder age, BMI, preoperative APTT, D-dimer, tumor histology, and surgery duration independently increased the risk of developing postoperative DVT/PE. These findings provide prognostic information that will guide therapies aimed at minimizing the development of DVT/PE during hospitalization.