Abstract
Postoperative pain is the most common complaint after laparoscopic cholecystectomy. This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy. Patients (ASA I or II) scheduled for laparoscopic cholecystectomy were randomly assigned into intramuscular dezocine group (group 1) or intramuscular normal saline group (group 2). Dezocine and equal volume normal saline were administered intramuscularly 10 min before the induction of anesthesia. After operation, the severity of postoperative pain, postoperative fentanyl requirement, incidence and severity of side-effects were assessed. Postoperative pain and postoperative patient-controlled fentanyl consumption were reduced significantly in group 1 compared with group 2. The incidence and severity of side effects were similar between the two groups. Preoperative single-dose administration of intramuscular dezocine 0.1 mg/kg was effective in reducing postoperative pain and postoperative patient-controlled fentanyl requirement in patients undergoing laparoscopic cholecystectomy.
Highlights
Postoperative pain is the most common complaint[1,2] and the primary reason for prolonged convalescence[3,4] after laparoscopic cholecystectomy
This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy under general anesthesia
Dezocine is an analgesic agent with opioid agonist and antagonist activity[20]
Summary
Postoperative pain is the most common complaint[1,2] and the primary reason for prolonged convalescence[3,4] after laparoscopic cholecystectomy. A synthetic bridged aminotetralin with minimum side effects and low dependence liability, is a parenterally administered opioid analgesic that has both agonistic and antagonistic actions at opioid receptors[7,8]. Dezocine was found to be 7 to 18 times as potent as morphine, and demonstrated slightly less antagonistic activity than nalorphine[9,10]. One study showed that dezocine did not suppress abstinence in withdrawn morphinedependent monkeys, nor did it produce dependence when administered chronically in monkeys[10]. Some studies showed that dezocine was found to possess less potential for producing bronchoconstriction, respiratory depression, hypotension, and histaminerelease than either morphine or pentazocine[11,12]. Dezocine was 8.6 times as potent as pentazocine in terms of respiratory depressant effects[13]. There are no reports on whether preoperative dezocine can reduce postoperative pain and the postoperative opioid requirement
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