Abstract
Summary A new series of diphenylalkylamine congeners of prenylamine have been assayed in binding experiments on rat striatal membrane preparations. The aim was to ascertain the influence of structural modifications and lipophilicity on their interaction with the [ 3 H]tyramine-labeled vesicular transporter for dopamine. Thirteen compounds potently inhibited the specific binding of [ 3 H]tyramine, with nanomolar K i , values in the range of those of established markers for the vesicular transporter of dopamine. Less lipophilic compounds displayed higher affinity for the energy-dependent amine transporter.
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