Abstract
The data on modern views on the problem of pre-cancerous changes (epithelial hyperplasia, squamous metaplasia, preneoplasia (dysplasia I) and neoplasia (dysplasia II-III) when squamous cell cancer and adenocarcinoma of the lung are summarizes in the present review. Atypical adenomatous hyperplasia, which is considered precancerous process for adenocarcinoma of the lung, due to the rare occurrence in the review is not considered. The attention is focused on the classification of morphological characteristics of precancerous changes in respiratory epithelium. The analysis of frequency and reversibility of preand neoplastic changes in bronchial epithelium. We discuss the connection between the nature of the changes of respiratory epithelium in the bronchi, developing simultaneously with squamous cell cancer or adenocarcinoma of the lung, with tumour progression.
Highlights
Kerr K.M. Preneoplastic and Preinvasive Lesions // Diagnostic Pulmonary Pathology
Ponticiello A., Barra E., Giani U. et al P53 immunohistochemistry can identify bronchial dysplastic lesions proceeding to lung cancer: a prospective study // Eur
The attention is focused on the classification of morphological characteristics of precancerous changes in respiratory epithelium
Summary
Kerr K.M. Preneoplastic and Preinvasive Lesions // Diagnostic Pulmonary Pathology. Ulmeanu R., Râjnoveanu R., Halic E. et al Natural course of preneoplastic bronchial lesions // Pneumologia. Wang G.F., Lai M.D., Yang R.R. et al Histological types and significance of bronchial epithelial dysplasia // Modern Pathology. Natural history of bronchial preinvasive lesions // Cancer Metastasis Rev. 2010.
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