Abstract
Administration of dexamethasone to mothers at risk of having children with CAH due to 21-OH deficiency is effective in suppressing fetal adrenals and preventing masculinisation of female external genitalia. Treatment should be started early, before the 7th week of gestation and should be administered as 2 or 3 divided doses. Compliance to treatment and efficacy of fetal adrenal suppression should also be carefully evaluated. The study presented here favours a daily dose of dexamethasone related to maternal size, i.e. 20–25 μg of dexamethasone per kg of maternal body weight at the time of onset of treatment. Mode of prenatal diagnosis would depend on the family and the facilities available locally.
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