Prenatal stress produces deficits in socio-sexual behavior of cycling, but not hormone-primed, Long–Evans rats

Abstract

Prenatal stress (PNS) alters behavior of adult offspring in novel environments or in social interactions; variable effects of PNS on female reproductive behavior have been reported. Effects of exposure to restraint and lights for 45 min/day on Gestational Days 14–20 were examined on the motor and socio-sexual behavior of adult female offspring. In a novel arena, proestrous PNS rats displayed greater behavioral inhibition as indicated by significantly fewer beam breaks made in the horizontal crossing task compared to that of proestrous non-PNS rats. In a standard mating test, in which females are exposed to males in a relatively small space for a restricted time or number of sexual contacts, PNS females in proestrus were found to have significant decreases in the intensity of lordosis and in the number of solicitation behaviors that they directed towards the male compared to non-PNS rats. In a seminatural mating test, in which females can control the timing of the sexual contacts from the male, PNS females in proestrus engaged in significantly less pacing of their sexual contacts compared to that of the non-PNS females. When additional PNS and non-PNS rats were ovariectomized (ovx) and tested following hormone priming, behavioral differences were abrogated. PNS decreased motor behavior in a novel arena, lordosis intensity, and solicitation behavior in a standard mating paradigm, as well as adaptive, approach–avoidance behavior in a seminatural mating situation of endogenously cycling proestrous rats but not ovx, hormone-primed rats. Thus, hormone priming may override or mask effects of PNS on some aspects of socio-sexual behavior.