Abstract
Previous epidemiological evidence mainly focused on the adverse effects of prenatal exposure to pyrethroid insecticides (PYRs) on respiratory health during childhood. It remains unclear whether the PYR exposures can also impact on children's lung function. To explore the potential effects of prenatal PYR exposures on lung function in a population of Chinese children. This study included 233 mother-child dyads from the Laizhou Wan Birth Cohort (LWBC), Shandong province, northern China, between September 2010 and December 2013. Three metabolites of PYRs [3-phenoxybenzoic acid (3-PBA), and cis- and trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (cis-DCCA and trans-DCCA)] were measured using gas chromatography-mass spectrometry (GC-MS) in maternal urine samples collected at recruitment. Lung function was assessed with spirometry in children aged 6-8 years. Multivariable linear regression and generalized linear models (GLMs) assessed the associations of prenatal PYR exposures with lung function in children. Among the PYR metabolites, 3-PBA (81.5%) were most frequently detected, followed by trans-DCCA (55.4%) and cis-DCCA (21.9%). The 3-PBA concentration was associated with a 1% decrease in FEV1/FVC in the highest quartiles of exposure compared to the lowest quartile, with a potential dose response association (p-trend=0.085). Our findings provide a suggestive effect modification by sex, with girls being more susceptible than the boys (p-trend=0.011). However, there were no associations between the trans-DCCA concentration and lung function parameters. Prenatal 3-PBA concentrations were associated with a modest decrease in FEV1/FVC among school-aged children, and the association was slightly more pronounced for the girls than for the boys.
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More From: International Journal of Hygiene and Environmental Health
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