Abstract
Abstract Objective To investigate the effects of prenatal progesterone exposure of male rats on testicular morphometry and histology. Methods Twenty male Wizard rats born to dams treated with hydroxyprogesterone hexanoate (HPH) during the first 2 weeks of gestation were employed to evaluate the effects of HPH on testicular morphometry, histology and cells quantities. Twenty male rats born to untreated dams were used as control. The rats were kept until they reached 90 days old, sacrificed, testes dissected, weighed and their dimensions recorded. Histological sections were prepared and stained with H & E. The diameter of the seminiferous tubule (ST), height of germinal epithelium, and thickness of the interstitial space (IS) were measured microscopically. Furthermore testicular cells were quantified. Results The results showed that experimental rats had significantly ( P Conclusions Prenatal HPH exposure of male rats adversely affects their testicular morphometry and histological structure and presumably has crucial negative effects on their future fecundity.
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