Abstract
Malaria Fetal immunity is generally thought to be skewed toward tolerance. Odorizzi et al. used samples from a study in Uganda to determine if placental malaria infection modulated fetal immune responses to malaria. They stimulated cord blood cells in vitro and found that the fetal cells from cases of placental malaria were more reactive to Plasmodium antigens. Moreover, clinical follow-up revealed that this increased T cell response correlated with protection from childhood malaria. Thus, protective immune responses in humans can develop even before birth. Sci. Transl. Med. 10 , eaat6176 (2018).
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