Prenatal origins of postnatal variation in growth, development and productivity of ruminants

Abstract

This review provides an update on recent research into the effects of maternal nutrition on fetal biology and the growth, development and productivity of progeny in postnatal life of ruminant livestock. Evidence is summarised for effects on postnatal growth and body composition, feed intake and efficiency, carcass characteristics and meat quality, wool production, reproduction and lactation performance. In general, these demonstrated effects are not large in relation to the effects of postnatal nutrition and other environmental influences. The mechanisms underpinning the above production outcomes are briefly discussed in terms of systemic endocrine and metabolic responses, and cellular and molecular effects in skeletal muscle, bone, adipose tissue, wool follicles and brain of fetal, neonatal and adult progeny. Treatments observed to elicit tissue responses include maternal under- and overnutrition at various stages of pregnancy and placental insufficiency caused by increased litter size, chronic maternal heat stress and premating carunclectomy in sheep. The as yet meagre evidence for epigenetic mediation of intergenerational effects in ruminants is considered, as is the likelihood that other, more conventional explanations may suffice in some cases. Finally, evidence is summarised for the proposition that the placenta is not merely a passive conduit for nutrient transfer from dam to fetus, but plays an active role in buffering the effects of variations in maternal nutrition on fetal growth and development, and thence, postnatal outcomes.